Publications by authors named "J C Hernaiz-Leonardo"
Background: Type 2 biologics have been used increasingly for the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP). However, patterns of biologic switching are understudied, and established guidelines for sequential or simultaneous use do not yet exist.
Methods: This is a Canadian multicenter retrospective study of real-world patient data.
Patients with chronic rhinosinusitis (CRS) that is refractory to maximal medical and surgical therapy should be evaluated for other primary conditions. Cystic fibrosis (CF), primary immunodeficiency (PID), and primary ciliary dyskinesia (PCD) are potential risk factors for refractory CRS. These conditions present with variable disease severity and diagnosis may be delayed into adulthood.
View Article and Find Full Text PDFArticle Synopsis
- - SinoNasal Microbiota Transfer (SNMT) showed safety and immediate benefits for all participants, with two out of three maintaining improvements for up to 180 days
- - The use of antimicrobial photodynamic therapy in combination with SNMT actually led to worse outcomes for chronic rhinosinusitis
- - These positive results from SNMT suggest that more research is needed to explore its safety and effectiveness further
Background: Although there are several endoscopic grading systems for chronic rhinosinusitis (CRS), they are limited in their range and applicability. We developed a SiNonasal Endoscopic Score (SiNES) that builds upon the strengths of previous systems while addressing their limitations.
Methods: The SiNES system was developed by consensus after multiple rounds of guided discussions.