Publications by authors named "J C Harshbarger"

The Functional ANnoTation Of the Mammalian genome (FANTOM) Consortium has continued to provide extensive resources in the pursuit of understanding the transcriptome, and transcriptional regulation, of mammalian genomes for the last 20 years. To share these resources with the research community, the FANTOM web-interfaces and databases are being regularly updated, enhanced and expanded with new data types. In recent years, the FANTOM Consortium's efforts have been mainly focused on creating new non-coding RNA datasets and resources.

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Article Synopsis
  • Long noncoding RNAs (lncRNAs) make up most of transcripts in mammalian genomes, but their functions are still not well understood.
  • The FANTOM6 project systematically knocked down 285 lncRNAs in human dermal fibroblasts and analyzed changes in cell growth, shape, and gene expression using CAGE techniques.
  • This study provides a comprehensive lncRNA knockdown data set (over 1000 CAGE sequencing libraries) and reveals important findings about their roles and impact on various cellular pathways.
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The prevalence of liver and skin tumors in brown bullhead ( Ameiurus nebulosus) from the Anacostia River (Washington, DC) and nearby areas was determined in 2014, 2015, and 2016. The objectives were to (1) compare tumor prevalence across space and time; (2) analyze the 1992-2016 Chesapeake Bay Tumor Database to identify reference locations and test age, length, weight, and sex as covariates; and (3) explore whether changes in bullhead exposure to contaminants can explain the observed trends. With logistic regression, we reported large statistically significant decreases in liver tumor probabilities in bullheads from the Anacostia CSX Bridge (ANAC) area between 1996 and 2001 (merged: female, 77.

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The authors regret that Luba M. Pardo was omitted in error from the author list of the original version of this Data Descriptor. This omission has now been corrected in the HTML and PDF versions.

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