Characterizing Cognitive Dispersion and its Correlates Across the Adult Lifespan in MIDUS.

Objectives: Although research has shown that higher levels of within-person variability across cognitive tasks (dispersion) are associated with cognitive decline in clinical samples, little is known about dispersion in comparatively younger, non-clinical, and national samples. A better understanding of dispersion is needed to elucidate for whom and under what circumstances dispersion can be used as a reliable indicator of cognitive health.

Method: We used data from the Midlife in the United States Study (MIDUS; n = 2,229; Mage = 56 years, range = 33-83; 56% female) to: (a) characterize dispersion and its cross-sectional correlates in a non-clinical, adult lifespan sample and (b) examine changes in dispersion over time to determine for whom changes in dispersion may reflect better or worse cognitive aging.

Age and anxiety symptoms jointly moderated the curvilinear changes in trial-level ERN following repeated errors on a Go/No-Go task during early adolescence.

The ability to detect and monitor errors enables us to maintain optimal performance across tasks. One neurophysiological index of error monitoring is the error-related negativity (ERN), a fronto-central negative deflection peaking between 0 and 150 ms following an erroneous response. While the developmental literature has illustrated age-related differences in the ERN and its association with anxiety, the literature has mainly focused on the between-person differences of the ERN.

Campus Sexual Assault: A Qualitative Review and Meta-Synthesis of Students' Experiences of Campus Prevention Initiatives.

Sexual violence is a worldwide issue that impacts many individuals, often with serious and long-lasting effects. Students represent a high-risk group for sexual violence on campuses. As a result, various government initiatives have called for Universities and Colleges to develop policies and sexual violence prevention initiatives.

Phase I study of allogeneic monocyte-derived inflammatory dendritic cells in combination with pembrolizumab.

PD-1 checkpoint inhibition has revolutionized the care of cancer. A small portion of patients with stage IV cancer achieve durable control. But, early progression is common and dramatic control is achieved for only a minority.

Modern Methods for Unraveling Cell- and Circuit-Level Mechanisms of Neurophysiological Biomarkers in Psychiatry.

Methods for studying the mammalian brain in vivo have advanced dramatically in the past two decades. State-of-the-art optical and electrophysiological techniques allow direct recordings of the functional dynamics of thousands of neurons across distributed brain circuits with single-cell resolution. With transgenic tools, specific neuron types, pathways, and/or neurotransmitters can be targeted in user-determined brain areas for precise measurement and manipulation.