Publications by authors named "J C Hahne"
Purpose: we tested whether ctDNA changes may be used to assess early response and clinical outcome in metastatic colorectal cancer (mCRC) patients undergoing front-line systemic anti-cancer therapy (SACT).
Experimental Design: 862 plasma samples were collected 4-weekly from baseline (BL) until disease progression in mCRC patients receiving front line SACT. ctDNA normalization was defined as ≥99% clearance after 1 month of therapy (Mo1) in the 3 variants with the highest allele frequency in BL ctDNA.
Article Synopsis
- - Patients with cancer often turn to the internet for guidance on medical decisions, and a study was conducted to analyze how ChatGPT responds to a hypothetical question about advanced cancer using a vignette of a patient with metastatic melanoma, adjusting for factors like age and insurance status.
- - The analysis revealed that responses varied significantly: younger patients (45 years old) received more mentions of clinical trials, while those with prior hospice recommendations saw more emphasis on seeking second opinions and hospice care.
- - ChatGPT generally highlighted hospice care's role in providing comfort and support, and it recognized the importance of involving family, particularly the patient’s adult daughter, in discussions about treatment preferences and values.
Malignant mesothelioma is a rare tumour caused by asbestos exposure that originates mainly from the pleural lining or the peritoneum. Treatment options are limited, and the prognosis is dismal. Although immune checkpoint blockade (ICB) can improve survival outcomes, the determinants of responsiveness remain elusive.
View Article and Find Full Text PDFWe describe a beamline where few-femtosecond ultraviolet (UV) pulses are generated and synchronized to few-cycle near-infrared (NIR) and extreme ultraviolet (XUV) attosecond pulses. The UV light is obtained via third-harmonic generation in argon or neon gas when focusing a phase-stabilized NIR driving field inside a glass cell that was designed to support high pressures for enhanced conversion efficiency. A recirculation system allows reducing the large gas consumption required for the nonlinear process.
View Article and Find Full Text PDFMetastatic gastric cancer (GC) still represents a critical clinical challenge, with limited treatment options and a poor prognosis. Most patients are diagnosed at advanced stages, limiting the chances of surgery and cure. The identification of molecular targets and the possibility of combining immune checkpoint inhibitors with chemotherapy have recently reshaped the therapeutic landscape of metastatic gastric cancer.
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