Publications by authors named "J C Guilland"
Aims: To study how MTHFR 677C→T genotype modulates the effect of supplementation with B-vitamins on total homocysteine (tHcy) and B-vitamin concentrations.
Methods: 2381 patients with a personal history of cardiovascular disease were randomly assigned to one of four groups: 1) B-vitamins alone (560 μg of 5-methyl-THF, 3 mg of vitamin B6 and 20 μg of vitamin B12), 2) n-3 fatty acids alone (600 mg of EPA and DHA in a 2:1 ratio), 3) B-vitamins and n-3 fatty acids, and 4) placebo. Participants were followed up for 4.
Objectives: We aimed to investigate whether SDMA- symmetric dimethylarginine -the symmetrical stereoisomer of ADMA- might be a marker of left ventricular function in AMI.
Background: Asymmetric dimethylarginine (ADMA) has been implicated in the prognosis after acute myocardial infarction (AMI) and heart failure (HF).
Methods: Cross sectional prospective study from 487 consecutive patients hospitalized <24 hours after AMI.
Background: The prevalence of 25-hydroxyvitamin D [25(OH)D] deficiency is high in patients presenting with an acute stroke, and it may be associated with greater clinical severity and a poor early functional prognosis. However, no data about its impact on long-term prognosis is available. In this study, we aimed to assess the association between 25(OH)D levels and 1-year mortality in stroke patients.
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- The study investigated how substrate availability affects fuel selection during exercise in endurance-trained cyclists, comparing performance in rested and fatigued conditions.
- Eight male cyclists completed a 90-minute exercise session while measuring lipid oxidation and lipolysis after ingesting sucrose.
- Results indicated that endurance exercise increases fat oxidation and influences fuel selection, emphasizing the importance of lipolysis and free fatty acid availability for effective fat utilization during physical activity.
Article Synopsis
- Recent interest in vitamin D has emerged due to its hormone-like effects on overall health.
- While earlier studies hinted at a connection between low vitamin D levels and an increased risk of chronic diseases, new research shows mixed results.
- Future randomized intervention studies are needed to establish clear guidelines for optimal vitamin D levels, particularly for calcium balance and bone health.