Publications by authors named "J C Goodall"
The circumstances under which species diversify to genetically distinct lineages is a fundamental question in biology. Atlantic herring (Clupea harengus) is an extremely abundant zooplanktivorous species that is subdivided into multiple ecotypes that differ regarding spawning time and genetic adaption to local environmental conditions such as temperature, salinity, and light conditions. Here we show using whole genome analysis that multiple populations of piscivorous (fish-eating) herring have evolved sympatrically after the colonization of the brackish Baltic Sea within the last 8000 years postglaciation.
View Article and Find Full Text PDFObjective: Genetic associations and blockade of the interleukin-23/IL-17 axis with monoclonal antibodies support a role for this pathway in psoriatic arthritis (PsA). This study examines the requirement of IL-23 for IL-17 production, and the role of the metabolic microenvironment in the expansion of Th-derived cells in PsA.
Methods: PsA patient synovial fluid or peripheral blood Th cell frequencies were evaluated by flow cytometry using CCR6, CD161 and T-bet as phenotypic markers, and the cytokines IFN-γ, GM-CSF and IL-17 assessed by flow cytometry and ELISA.
Supporting Transgender, Nonbinary, and Gender Diverse Youth During Solid Organ Transplantation.
Pediatr Transplant
February 2025
Article Synopsis
- As society increasingly accepts gender diversity, healthcare systems need to adapt by offering supportive and inclusive care for gender diverse individuals, especially in pediatric solid-organ transplant programs.* -
- This review highlights key principles of gender-affirming care and focuses on how transplant teams can effectively meet the needs of young gender diverse patients during solid organ transplants.* -
- Using kidney transplants as a case study, it discusses the integration of gender-affirming hormone therapy, surgery, interpretation of lab values, and the necessity of personalized care for gender diverse individuals in transplant settings.*
Article Synopsis
- - PARP inhibitors show promise in treating castration-resistant prostate cancer (CRPC) with homologous recombination repair (HRR) defects, but the reasons behind resistance are not completely understood.
- - A study from the TOPARP-B trial found that 79% of BRCA2/PALB2-mutated tumors exhibited reversion mutations at the end of treatment, with many related to POLQ-mediated DNA repair mechanisms.
- - In cases of BRCA2 homozygous deletions, rare subclones lacking the BRCA2 deletion are selected for after PARP inhibitor treatment, indicating the necessity for restored HRR function in developing resistance.
Aims: Heart failure and associated cachexia is an unresolved and important problem. This study aimed to determine the factors that contribute to cardiac cachexia in a new model of heart failure in mice that lack the integrated stress response (ISR) induced eIF2α phosphatase, PPP1R15A.
Methods And Results: Mice were irradiated and reconstituted with bone marrow cells.