Examining Interventions for Pediatric Adverse Childhood Experiences in an Integrated Primary Care Setting.

Introduction: Adverse Childhood Experiences (ACEs) increase the risk of chronic diseases in adulthood and contribute to neurobehavioral challenges during childhood and adolescence.

Method: This retrospective study reviewed the medical records of 102 pediatric patients to describe interventions for children screening positive for ACEs in a pediatric primary care setting with integrated behavioral health services. It further assessed whether these interventions led to improvements in psychosocial functioning and mood.

Planning for Long-Term Recovery: The Impact of COVID-19 on Educators Working With Children From Seasonal and Migrant Farmworker Families.

Background: Education faced challenges during the COVID-19 pandemic. Although the United States has declared an end to the public health emergency, schools continue to be impacted. While considerable research has focused on the impact of the pandemic on students, fewer studies have focused on educators, and even less on educators who specialize in working with marginalized student populations.

Feedback modulation of Orai1α and Orai1β protein content mediated by STIM proteins.

Store-operated Ca entry is a mechanism controlled by the filling state of the intracellular Ca stores, predominantly the endoplasmic reticulum (ER), where ER-resident proteins STIM1 and STIM2 orchestrate the activation of Orai channels in the plasma membrane, and Orai1 playing a predominant role. Two forms of Orai1, Orai1α and Orai1β, have been identified, which arises the question whether they are equally regulated by STIM proteins. We demonstrate that STIM1 preferentially activates Orai1α over STIM2, yet both STIM proteins similarly activate Orai1β.

Assessment of adverse childhood experiences in adolescents from a rural agricultural community: Associations with depressive symptoms and psychosocial problems.

The main goal of this study was to determine the prevalence of adverse childhood experiences (ACEs) among Latino adolescents from an agricultural community and to examine how it may impact their neuropsychiatric functioning. This research particularly assessed the association between ACEs and depression, as well as ACEs and psychosocial problems. The study sample consisted of 852 adolescents treated at a rural primary care clinic with a comprehensive ACE screening protocol that assesses for ACEs, depressed mood, and psychosocial functioning during every annual Well-Child Visit.