Sparse Negative Binomial Signal Recovery for Genomic Variant Prediction in Diploid Species.

Structural variants (SVs) - such as insertions, deletions, and duplications of an individual's genome - are associated with genetic diseases and promotion of genetic diversity. Detecting SVs of an unknown genome is a mathematically challenging problem since SVs are rare and prone to low-coverage noise. Common approaches to detect SVs in an unknown genome require sequencing fragments of the genome, comparing them to a high-quality reference genome, and predicting SVs based on identified discordant fragments.

Specific neuroblast-derived signals control both cell migration and fate in the rostral migratory stream.

Functional neuronal circuits require neuroblasts migrate to appropriate locations and then differentiate into neuronal subtypes. However, it remains unknown how neuroblasts in the subventricular zone (SVZ) are guided through the rostral migratory stream (RMS) to the olfactory bulb (OB). Here we define EphB2 as a neuroblast-derived cue that controls migration along the RMS and helps to determine cell fate.

Chimeric antigen receptor T cell therapy in octogenarians with B cell lymphoma: a real-world US multicenter collaborative study.

Older patients with lymphoma are typically underrepresented in clinical trials with chimeric antigen receptor T cell (CAR T) therapy. In this multicenter, observational study we aimed to assess the safety and efficacy of standard CD19 CAR T in patients 80 years of age or older. At total of 88 patients, median age 82 (range, 80-89) years, were included.

Predictive Value of Gene Expression in Chemotherapy Response in Breast Cancer.

: Breast cancer is the most commonly diagnosed cancer among women, and resistance to chemotherapy presents a significant challenge in its treatment. Stanniocalcin-2 (STC2), a glycoprotein involved in calcium homeostasis and cellular stress responses, is frequently overexpressed in various human cancers. Despite its critical role in cellular adaptation to stress, the potential of as a biomarker for predicting chemotherapy response has not been evaluated.

Changes in Sexual Functioning in Women with Severe Obesity After Bariatric Surgery: Impact of Postoperative Adherence to Mediterranean Diet.

Background: This study analyzes the effects of bariatric surgery on female sexual function, assessed using the Female Sexual Function Index (FSFI), and explores the impact of adherence to the Mediterranean diet during the postoperative period.

Patients And Methods: A retrospective observational study was conducted using a prospectively collected database, including heterosexual women with morbid obesity undergoing bariatric procedures. The FSFI questionnaire was applied before the intervention and 24 months after surgery.