Publications by authors named "J C G Doery"
Article Synopsis
- Adrenal vein sampling (AVS) is the preferred method for identifying unilateral subtypes of primary aldosteronism (PA), which can be treated with surgery for a potential cure.
- The procedure is technically demanding and often performed by specialized interventional radiologists, but variations in protocols can affect its success and patient care.
- To standardize AVS practices and improve outcomes, an Australian and New Zealand AVS Working Group was formed to create expert consensus recommendations that can be utilized by all healthcare professionals involved in PA management.
Context: Transgender people with sex recorded male at birth desiring feminization commonly use cyproterone acetate or spironolactone as anti-androgens with estradiol, but the optimal anti-androgen is unclear.
Objective: To assess the effect of anti-androgens on breast development. We hypothesized this would be greater in those treated with cyproterone acetate than spironolactone due to more potent androgen receptor antagonism and suppression of serum total testosterone concentrations.
The where, who and how of adrenal vein sampling in Australia and New Zealand.
J Med Imaging Radiat Oncol
February 2024
Introduction: Primary aldosteronism (PA) causes 10-15% of cases of hypertension, and it is increasingly recognised as being under-diagnosed. An interventional radiology procedure, adrenal vein sampling (AVS), is a necessary and important diagnostic procedure for complete workup of PA. There is an anticipated increase in demand for AVS as detection of PA improves.
View Article and Find Full Text PDFObjectives: The saline suppression test (SST) serves to confirm the diagnosis of primary aldosteronism (PA), while adrenal vein sampling (AVS) is used to subtype PA as unilateral or bilateral. Criteria that can accurately identify those with bilateral PA based on SST results could reduce the need for AVS. We previously demonstrated that a combination of plasma aldosterone concentration (PAC) < 300 pmol L-1 and a reduction in aldosterone-to-renin ratio (ARR) following recumbent SST had high specificity for predicting bilateral PA in an Australian cohort of 92 patients with PA who have undergone AVS.
View Article and Find Full Text PDFContext: The plasma aldosterone concentration (PAC), renin, and aldosterone-to-renin ratio (ARR) are used to screen for primary aldosteronism (PA). Substantial intra-individual variability of PAC and ARR using plasma renin activity in the context of usual antihypertensive therapy has been described, but there is no data on ARR variability calculated using direct renin concentration (DRC).
Objective: To describe the intra-individual variability of PAC, DRC, and ARR in the absence of interfering medications in patients with and without PA.