Pregnancy specific shifts in the maternal microbiome and metabolome in the BPH5 mouse model of superimposed preeclampsia.

Preeclampsia (PE) is a life-threatening hypertensive disorder of pregnancy with an incidence rate of up to 8% worldwide. However, the complete pathogenesis is still unknown. Obesity increases the risk of developing PE three-fold.

The needs of informal caregivers of people experiencing dementia as identified on social media.

Objectives: The aims of this study were to 1) categorize and quantify the most frequent concerns of informal caregivers, 2) conduct a thematic analysis on a sample of the posts, and 3) examine a subset of 100 post responses to determine if they are supportive and evidence- based.

Method: For Aims 1 and 2, we used a qualitative descriptive design using content analysis. To address Aim 3, we used a Delphi method in a subset sample of responses to posts to determine if they were supportive or not and evidence-based or not.

Population-specific reference panel improves imputation quality for genome-wide association studies conducted on the Japanese population.

To improve imputation quality for genome-wide association studies (GWAS) conducted on the Japanese population, we developed and evaluated four Japanese population-specific reference panels. These panels were constructed through the augmentation of the 1000 Genomes Project (1KG) panel using Japanese whole genome sequencing (WGS) data, with sample sizes ranging from 1 K to 7 K individuals enrolled through the Biobank Japan (BBJ) project, and sequencing depths ranging from 3× to 30×. Among these panels, an augmented reference panel comprising 7472 WGS samples of mixed depth (1KG+7K) exhibit the greatest improvement in imputation quality relative to the Trans-Omics for Precision Medicine (TOPMed) reference panel.

Risk factors and outcomes of renal insufficiency after colectomy for diverticulitis.

Background: Diverticulitis has significantly increased in prevalence in recent decades, requiring higher rates of colon resections. While current literature focuses on postoperative complications such as abscesses, wound infections, and anastomotic leaks, many are limited in showing details regarding the significant risk associated with developing renal insufficiency among diverticulitis patients undergoing colectomy.

Methods: We selected patients from the 2022 National Surgical Quality Improvement Program (NSQIP) Colectomy database who underwent colon resection for diverticulitis using International Classification of Disease (ICD10) code K57.

Overweight and obese body condition in ∼4.9 million dogs and ∼1.3 million cats seen at primary practices across the USA: Prevalences by life stage from early growth to senior.

Adult dogs and cats in overweight or obese condition are common, but prevalence data for different life stages, especially growth, are limited, and may help inform when preventative measures may be most effective. In this retrospective observational study, prevalences of overweight and obese condition were determined from the electronic medical records of dogs and cats of all life stages visiting Banfield Pet Hospital in the USA between 2020 and 2023. Animals were identified either by body condition score (BCS; overweight 6-7; obese 8-9) or from a clinical diagnosis of overweight condition or obesity when recorded.