Publications by authors named "J C Fernandez-Macias"

Background: Cardiovascular disease (CVD) is one of the main causes of death and disability worldwide. The etiology of CVD is often associated with multiple risk factors, with environmental factors receiving considerable attention. Individuals with precarious jobs are among the groups most affected by chronic exposure to environmental pollutants.

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Microplastics (MPs) have attracted global interest because they have been recognized as emerging pollutants that require urgent attention. MPs are plastic particles with a size between 1 micron and 5 mm (1 µm-5mm); those measuring less than 1 µm are known as nanoplastics (NPs). MP is distributed in the environment in various physical forms that depend on the degradation process, the erosion factors to which it was subjected, or the original form in which it was intentionally manufactured.

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Article Synopsis
  • Cardiovascular diseases (CVDs) are the top cause of illness and death globally, with both genetic and environmental factors impacting their development, but their interaction remains unclear.
  • A study involving 390 healthy Mexican women examined the combined effect of the MTHFR C677T genetic polymorphism and exposure to polycyclic aromatic hydrocarbons (PAHs) on cardiovascular risk biomarkers.
  • Results indicated that higher urinary PAH levels were linked to elevated serum markers of cardiovascular risk, particularly in women with the TT genotype of the MTHFR enzyme, highlighting the need for targeted health interventions.
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Background: Fluoride is an inorganic element, which can be found in high concentrations in groundwater. Its consumption and exposure have consequences on human health. The objective of this study was to evaluate fluoride exposure and develop a health risk assessment in children from an urban area with hydrofluorosis in Mexico.

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Exosomes are vesicles, ranging of 30-150 nm in diameter, which are released by different cell types into the extracellular space. Exosomes are capable of transporting several biomolecules such as proteins, lipids, DNA, mRNA, and non-coding RNA, including microRNAs (miRs). miRs signatures have been linked to the development of non-communicable diseases and their classification into various subtypes and/or stages.

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