Publications by authors named "J C Eck"
Observations from multisensory body illusions indicate that the body representation can be adapted to changing task demands, e.g., it can be expanded to integrate external objects based on current sensorimotor experience (embodiment).
View Article and Find Full Text PDFProtection against (EPS) challenge seems to be genotype-serotype-specific.Genotype B (O78:H4) gave (almost) full protection against genotypes B, F and H (all O78:H4).Genotype D (O11:H12) incited partial protection.
View Article and Find Full Text PDFMotivation: Hydrophobic patches on protein surfaces play important functional roles in protein-protein and protein-ligand interactions. Large hydrophobic surfaces are also involved in the progression of aggregation diseases. Predicting exposed hydrophobic patches from a protein sequence has shown to be a difficult task.
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- Pathogenic missense variants in the synaptic vesicle protein synaptotagmin-1 (SYT1) lead to a neurodevelopmental disorder with motor delays, intellectual disabilities, and visual impairments due to impaired neurotransmitter release.
- Research on cultured neurons has shown that specific variants in the SYT1 protein hinder exocytosis, causing varying degrees of dysfunction based on the variant's location.
- The study establishes a direct correlation between the exocytic efficiency of SYT1 variants and the severity of developmental impairments, indicating a clear relationship between genetic mutations, neurotransmitter release, and functional outcomes, paving the way for potential therapeutic approaches.
The impact of the emerging tick-borne pathogen Borrelia miyamotoi is not fully understood. We utilised a protein array to investigate B. miyamotoi seroreactivity in various human populations in the Netherlands and Sweden.
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