Publications by authors named "J C Duche"
Article Synopsis
- HSA (Human Serum Albumin) and AGP (Alpha-1 Acid Glycoprotein) are the main plasma proteins that bind drugs tightly, influencing their distribution and elimination.
- Restrictive binding by these proteins can affect how long a drug stays active in the body, while low binding (permissive) allows drugs to move freely without significant retention.
- Changes in how these proteins bind drugs can impact other pharmacokinetic factors and have important effects on treatment outcomes.
[Plasma vitamin B12 assay on ACS180 Bayer diagnostics. Comparison with a radioligand binding assay].
Ann Biol Clin (Paris)
December 2001
Study Objective: The aim of the study was to assess diagnosis value of tumor markers for differential diagnosis between mesothelioma and other pleural tumors.
Design And Methods: Prospective study of 85 patients attending our hospital with malignant pleural effusion. The diagnostic approach involved routine pleurocentesis followed by pleural needle.
Objectives: We have investigated the AAG and its genetic variants concentrations in plasma samples of 61 patients suffering from different types of cancers.
Design And Methods: The patients were shared out in three groups, breast, lung, and ovary cancers groups. AAG concentration was measured by an immunonephelometric method and the phenotype was determined, after desialylation of plasma by analytical isoelectric focusing.
The binding of CPT-11 and SN-38 to human plasma proteins was studied by ultrafiltration at 37 degrees C and pH 7.4. In plasma, CPT-11 was 66-60% bound in the range 100-4000 ng/ml and SN-38 was 94-96% bound in the range 50-200 ng/ml.
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