Publications by authors named "J C Dick"
Leukemic stem cells (LSCs) fuel acute myeloid leukemia (AML) growth and relapse, but therapies tailored towards eradicating LSCs without harming normal hematopoietic stem cells (HSCs) are lacking. FLT3 is considered an important therapeutic target due to frequent mutation in AML and association with relapse. However, there has been limited clinical success with FLT3 drug targeting, suggesting either that FLT3 is not a vulnerability in LSC, or that more potent inhibition is required, a scenario where HSC toxicity could become limiting.
View Article and Find Full Text PDFNon-native species can be major drivers of ecosystem alteration, especially through changes in trophic interactions. Successful non-native species have been predicted to have greater resource use efficiency relative to trophically analogous native species (the Resource Consumption Hypothesis), but rigorous evidence remains equivocal. Here, we tested this proposition quantitatively in a global meta-analysis of comparative functional response studies.
View Article and Find Full Text PDFArticle Synopsis
- T-lineage acute lymphoblastic leukemia (ALL) presents as an aggressive cancer with diverse subtypes, making traditional classification difficult.
- A multiomics analysis of bone marrow samples revealed a specific subset of T-lineage ALL with active inflammatory and stem gene programs, showing unique biological and treatment response characteristics.
- A computational inflammatory gene signature scoring system was developed to better classify patients, identifying a high-risk subtype that could guide targeted therapies for more effective treatment approaches.