The effect of midazolam on motility of the sphincter of Oddi in human subjects.

Midazolam, a water-soluble benzodiazepine, has recently been introduced and found to be beneficial for sedation in upper GI endoscopy. Whereas it has been proven that diazepam does not have any effect on sphincter of Oddi (SO) motility in humans, no respective data exist on midazolam. On evaluation of the possible effects of midazolam on SO motility recording by means of endoscopic manometry, we found that midazolam had no effect on basal pressure (24.

Effects of buprenorphine on motor activity of the sphincter of Oddi in man.

Buprenorphine, (Temgesic), a N-cyclopropylmethyl derivative of oripavine, is both an agonist and antagonist of morphine. Its effect on the motility of the sphincter of Oddi (SO) in humans have been investigated by endoscopic manometry (EM). Buprenorphine leads to a significant decrease in the amplitude of SO contraction waves without altering other parameters.

[Inverted polypoid hamartoma of the rectum].

The inverted polypoid hamartoma of the rectum (IPHR) is characterized by polypoid masses composed of ectopic glands of Lieberkühn invaginated within the mucosal muscle to form a conglomeration in the submucosa, hence the term "inverted polyp". It produces an unremarkable rectal syndrome, more suggestive, when abundant glairy exudate is observed, in young subjects. It causes a unique sessile polypoid lesion, occasionally multilobular or a stenotic, approximately circular, ring.