Publications by authors named "J C Couture"
Article Synopsis
- - Complex associating with SET1 (COMPASS) is a histone methyltransferase that includes the regulatory subunit Cfp1, which plays a key role in recognizing the methylation of histone H3 at lysine 4 (H3K4me3).
- - Research shows that while the yeast analog Spp1 has a specific structure for H3K4me3 recognition, metazoan Cfp1 lacks certain structural elements, leading to a unique binding configuration for H3K4me3.
- - Mutations in Cfp1 linked to cancer disrupt its ability to bind H3K4me3, suggesting these mutations may affect important epigenetic signaling pathways.
Background: Depressive and anxiety symptoms are common in childhood-onset systemic lupus erythematosus (cSLE), yet their etiology and course remain unclear. We investigated the frequency of depressive and anxiety symptoms longitudinally in youth with cSLE, and associated socio-demographic and disease factors.
Methods: Participants 8-18 years with cSLE completed baseline measures [demographic questionnaire, Center for Epidemiologic Studies Depression Scale for Children (CES-DC), Screen for Childhood Anxiety Related Disorders (SCARED), and psychiatric interview] and follow-up measures (CES-DC and SCARED) > 6 months later.
Background: The use of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in nephrology practice is increasingly becoming standard of care in patients with diabetes or those with proteinuria.
Objectives: The primary outcome was to identify the proportion of pre-dialysis patients with chronic kidney disease (CKD) G3a, G3b, or G4 prescribed an SGLT2i and describe their characteristics.
Methods: This was a retrospective, multicentric, cross-sectional study of patients with CKD followed at 4 pre-dialysis clinics in the province of Quebec, Canada.
The global population consumes more seafood from aquaculture today than from capture fisheries and although the aquaculture industry continues to grow, both seafood sectors will continue to be important to the global food supply into the future. As farming continues to expand into ocean systems, understanding how wild populations and fisheries will interact with farms will be increasingly important to informing sustainable ocean planning and management. Using a spatially explicit population and fishing model we simulate several impacts from ocean aquaculture (i.
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