Colocalization of MCM8 and MCM7 with proteins involved in distinct aspects of DNA replication.

Minichromosome maintenance (MCM) proteins are essential for DNA replication in eukaryotes. A subcomplex of the MCM2-7 family members, initially characterized in yeast, is thought to serve as a eukaryotic DNA replicative helicase. MCM8 is a new family member, not present in yeast, which may function alone or with other family members in aspects of DNA metabolism, including replication initiation and elongation.

Pathogenicity of aeromonas.

The ability of 15 Aeromonas sobria and 9 Aeromonas hydrophila isolates to cause subcutaneous lesions was tested. An inoculum of 10(11) colony forming units/l was injected subcutaneously into mice. Surviving animals developed a subcutaneous abscess and/or localised skin sloughing and loss of hair (alopecia).

Changes in the bacterial flora of the external ear canal from the wearing of occlusive equipment.

External otitis has been associated with wearing obstructive gear covering the earlobe and external ear canal. In this study we investigated the changes in the bacterial flora of the external ear canal after wearing rubber hoods. The bacterial flora of external ear canals surfaces was investigated in a group of 19 volunteers who wore rubber hoods for a period of 25 to 30 minutes while doing manual work.

Pathogenicity of piliated and encapsulated Bacteroides fragilis.

Of 20 isolates of the Bacteroides fragilis group, only three were encapsulated (C+) and these induced abscesses in mice. After coinoculation with live, formalized or capsular material from other bacteria seven other isolates formed abscesses. The Bacteroides recovered from these abscesses were C+; those that had been inoculated with Klebsiella had pili-like and bacteriophage-like structures.