Publications by authors named "J C Chua"
Introduction: Diagnostic performance of optical coherence tomography (OCT) to detect Alzheimer's disease (AD) and mild cognitive impairment (MCI) remains limited. We aimed to develop a deep-learning algorithm using OCT to detect AD and MCI.
Methods: We performed a cross-sectional study involving 228 Asian participants (173 cases/55 controls) for model development and testing on 68 Asian (52 cases/16 controls) and 85 White (39 cases/46 controls) participants.
Objectives: To examine the predictors of parent-child bonding and parenting satisfaction using structural equation models at three time points across the perinatal period: (1) during pregnancy at >24 gestational weeks, (2) one month postpartum, and (3) three months postpartum.
Methods: This longitudinal exploratory quantitative study recruited a convenient sample of 118 heterosexual couples (236 participants; 118 mothers and 118 fathers) from maternity clinics of a public tertiary hospital in Singapore. Descriptive statistics were used to summarize the parents' characteristics and study variables.
Aims: This study aims to identify factors associated with mental health literacy (mental health knowledge and attitudes towards mental health and help-seeking behaviours), depression and anxiety amongst adolescents, and test the hypothesised model by examining the interrelationships between these outcomes.
Design: Cross-sectional descriptive quantitative research.
Methods: Using convenient sampling, 615 adolescents from four public schools completed online questionnaires measuring mental health literacy, depression, and anxiety.
Article Synopsis
- Accurate diagnosis of Alzheimer's disease and vascular dementia is vital for timely treatment and better patient outcomes; this study focused on plasma and retinal biomarkers for differentiation among cognitive impairment groups.
- The study involved 509 participants aged 50 and older, categorized into groups based on cognitive function using clinical assessments, neuropsychological tests, and MRI scans.
- The findings revealed that both retinal layer thickness and plasma biomarker levels varied significantly across cognitive impairment levels, with decreases seen in retinal thickness and increases in plasma biomarkers from normal cognition to dementia.