Publications by authors named "J C Chevre"
Article Synopsis
- A study identified 14 low-frequency genetic variants linked to body mass index (BMI) in a large group of mostly European individuals.
- The research aimed to evaluate how two genetic scores (GS) related to obesity risk, BMI changes before and after lifestyle interventions, and outcomes after bariatric surgery.
- Findings showed that while the risk GS didn't correlate with severe obesity or pre-intervention BMI, BMI-decreasing variants were less common in obese individuals; however, the protective GS led to more significant BMI decreases after bariatric surgery and influenced the likelihood of weight regain.
Achieving immunoregulation expansion of Foxp3 regulatory CD4 T cells (Treg) remains challenging. We have shown that mobilization confers to multipotent hematopoietic progenitors (MPPs) the capacity to enhance Treg proliferation. Transcriptomic analysis of Tregs co-cultured with MPPs revealed enhanced expression of genes stabilizing the suppressive function of Tregs as well as the activation of IL-1β-driven pathways.
View Article and Find Full Text PDFObesity has become a major worldwide challenge to public health, owing to an interaction between the Western 'obesogenic' environment and a strong genetic contribution. Recent extensive genome-wide association studies (GWASs) have identified numerous single nucleotide polymorphisms associated with obesity, but these loci together account for only a small fraction of the known heritable component. Thus, the 'common disease, common variant' hypothesis is increasingly coming under challenge.
View Article and Find Full Text PDFArticle Synopsis
- A1C is a key marker for monitoring blood glucose levels, and a genetic variant (rs7072268) in the HK1 gene is linked to increased A1C levels, but not to other glucose control markers.
- The study involved analyzing data from nearly 30,000 individuals to examine the effects of this variant on A1C and red blood cell traits, revealing a significant link between the variant and lower hemoglobin levels and higher anemia risk.
- The conclusions suggest that the impact of HK1 on A1C might be mediated through its influence on anemia rather than directly affecting glucose metabolism, which could affect type 2 diabetes management.
Article Synopsis
- * We found significant associations with obesity for 38 genetic markers, which were further tested in a larger group of 14,186 Europeans.
- * In addition to previously known genes (FTO and MC4R), we identified three new risk loci linked to obesity: NPC1, MAF, and PTER.