Publications by authors named "J C Champey"
Article Synopsis
- A study examined low-dose interleukin-2 (IL-2) as a treatment for 13 different autoimmune diseases, focusing on its ability to activate regulatory T cells (Tregs) which are crucial in managing these conditions.
- 81 patients received IL-2 over a span of treatment, resulting in significant Treg expansion and activation, with clinical improvements noted in the majority of the diseases assessed, particularly in conditions like ankylosing spondylitis and systemic lupus erythematosus.
- The findings suggest that IL-2 is well-tolerated and effective at targeting Tregs, indicating its potential as a valuable addition to future therapeutic strategies for autoimmune diseases.
Beyond its effect on vegetative functions, the activation of the vagus nerve inhibits inflammation and reduces pain signaling. The aim of this open-label pilot study was to determine the efficacy and tolerance of transcutaneous auricular VNS (taVNS) on erosive hand osteoarthritis (EHOA) symptoms. Symptomatic EHOA patients with hand pain VAS ≥ 40/100 mm and ≥1 interphalangeal swollen joint(s) were included.
View Article and Find Full Text PDFObjective: Regulatory T cells (Tregs) prevent autoimmunity and control inflammation. Consequently, any autoimmune or inflammatory disease reveals a Treg insufficiency. As low-dose interleukin-2 (ld-IL2) expands and activates Tregs, it has a broad therapeutic potential.
View Article and Find Full Text PDFObjective: Various strategies have been proposed to reduce the incidence of external ventricular drain (EVD)-related infections. The authors retrospectively studied the impact of EVD care management on EVD-related infections at 3 French university hospital intensive care units.
Methods: Between 2010 and 2014, 462 consecutive adult patients with no evidence of a preexisting CSF infection received EVDs as part of their care at one of the following sites: Grenoble (221 patients), Saint-Etienne (130 patients), and Marseille (111 patients).
Background: An extended course of tetanus (up to 6 weeks) requiring ICU admission and protracted mechanical ventilation (MV) may have a significant impact on short- and long-term survival. The subject is noteworthy and deserves to be discussed.
Methods: Twenty-two ICUs in France performed tetanus screenings on patients admitted between January 2000 and December 2014.