Publications by authors named "J C Chamcheu"
Members of the genus including Jurona virus (JURV) have emerged as promising immunotherapeutic agents, characterized by their tumor selectivity, fast kinetics, low seroprevalence, and minimal toxicity in humans. Here, we demonstrate that the administration of JURV leads to tumor regression in both hepatocellular carcinoma (HCC) xenograft and syngeneic models. Furthermore, our findings indicate that combining JURV and anti-PD-1 therapy reduced tumor burden and improved survival rates over JURV or anti-PD-1 alone in an orthotopic HCC model.
View Article and Find Full Text PDFSince the early 20th century, the increase in non-communicable diseases such as diabetes, heart disease, stroke, and cancer compared to infectious diseases has led to chronic illnesses becoming a leading cause of global morbidity and mortality [...
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- - Transduction of molecular signaling is how cells communicate both with each other and their surroundings through chemical or physical signals.
- - This process is crucial for maintaining the cell's structure and integrity.
- - It also triggers various physiological responses necessary for the cell's function and survival.
Article Synopsis
- About 25% of people with a type of pancreatic cancer called PDAC can't have surgery or have advanced stages, and treatments like chemotherapy and radiation haven't worked well for them.
- Removing these tumors is hard because of their size and how they connect to nearby blood vessels.
- A new treatment using special viruses could help by breaking down tough parts of the tumor, allowing better access for other treatments and possibly making the tumors smaller.
Article Synopsis
- Cannabis and its major cannabinoid, cannabidiol (CBD), show potential anticancer effects against skin tumors, particularly melanoma.
- In experiments, CBD exhibited significant cytotoxicity, with IC values of 28.6 and 51.6 μM against murine (B16F10) and human (A375) melanoma cells, respectively.
- Synthetic CBD derivatives with bipiperidinyl groups demonstrated even greater cytotoxicity, suggesting that these compounds could be effective in treating melanoma by inducing apoptosis in cancer cells.