Publications by authors named "J C Cappelleri"
Background: Long COVID remains a significant public health concern. This study investigated risk factors for long COVID in outpatient settings.
Methods: A US-based prospective survey study (clinicaltrials.
Article Synopsis
- The study focused on evaluating the effects of tofacitinib on fatigue in patients with ankylosing spondylitis (AS) through a phase 3 randomized controlled trial.
- Results showed that patients taking tofacitinib experienced a faster improvement in fatigue symptoms compared to those on a placebo, with significant percentages achieving noticeable relief within 16 weeks.
- The findings suggest that tofacitinib may be an effective treatment option for quickly alleviating fatigue in AS patients, providing healthcare providers with valuable information when discussing treatment plans with their patients.
Purpose: To evaluate patient-reported health-related quality-of-life (QoL) in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced/metastatic breast cancer (ABC) treated with palbociclib in the longitudinal real-world study, POLARIS.
Methods: Data were prospectively collected from adult patients with HR+/HER2- ABC treated with palbociclib plus endocrine therapy (ET) in routine clinical practice. QoL was assessed with the European Organisation for Research and Treatment of Cancer Quality-of-Life Questionnaire-Core 30 (EORTC QLQ-C30) and reported at baseline and months 6, 12, and 18.
Symptoms post-SARS-CoV-2 infection may persist for months and cause significant impairment and impact to quality of life. Acute symptoms of SARS-CoV-2 infection are well studied, yet data on clusters of symptoms over time, or post-acute sequelae of SARS-CoV-2 infection (PASC), are limited. We aim to characterize PASC phenotypes by identifying symptom clusters over a six-month period following infection in individuals vaccinated (boosted and not) and those unvaccinated.
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- The study investigated long COVID symptom patterns among COVID-19 patients, identifying clusters based on how many symptoms co-occurred and examining their effects on Health-Related Quality of Life (HRQoL) and work productivity.
- It involved 328 participants divided into three groups: low (less than 2 symptoms), moderate (2-6 symptoms), and high (more than 6 symptoms) symptom burden, with higher symptom counts linked to poorer HRQoL and work productivity.
- Vaccinated individuals with the BNT162b2 vaccine reported fewer symptoms over time compared to those unvaccinated, suggesting that vaccination may help reduce the burden of long COVID symptoms.