Publications by authors named "J C Buckey"
Persistent cognitive fatigue (CF) is the most reported symptom in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), but little is known about its underlying neural basis. This pilot study examined fMRI brain activation patterns during a fatiguing task in those with and without PASC. We hypothesized that individuals with PASC would show changes in CF-related brain activation within fatigue network.
View Article and Find Full Text PDFObjective: Children with HIV (CWH) are at increased risk for cognitive and developmental delays, although HIV's influence on reading development remains unclear. Research using internationally validated reading measures with control for factors known to influence literacy outcomes is needed. The Early Grade Reading Assessment (EGRA) is a tool for assessing students' progress toward reading that has been validated across countries.
View Article and Find Full Text PDFClinical Trial Design Considerations for Hospitalised Patients With Ulcerative Colitis Flares and Application to Study Hyperbaric Oxygen Therapy in the NIDDK HBOT-UC Consortium.
Aliment Pharmacol Ther
December 2024
Article Synopsis
- Patients with ulcerative colitis (UC) experiencing severe flares in the hospital are a unique and high-risk group requiring specialized clinical trial designs.
- A multi-centre consortium is developing a trial for hyperbaric oxygen therapy, addressing important factors like inclusion/exclusion criteria, disease activity measures, and tailored care pathways.
- The study highlights the need for comprehensive outcome measures and standardized care practices while emphasizing the significance of early intervention and statistical planning in these small clinical trials.
Article Synopsis
- Hyperbaric oxygen (HBO) therapy is gaining attention for treating conditions beyond its established uses, particularly due to its effects on hypoxia and inflammation.
- A web-based International Multicenter Registry collects data from various centers to analyze HBO treatment outcomes and identify new potential applications across different medical specialties.
- The study found that out of 9,726 patients, 378 were treated for 45 new indications, with a significant number related to post-COVID-19 conditions, ulcerative colitis, and Crohn's disease.