Publications by authors named "J C Bird"
Background: Abnormalities of left ventricular (LV) diastolic function are established independent predictors of heart failure (HF) and mortality.
Objectives: To determine whether the association of diastolic function with all-cause mortality is driven by cardiovascular or non-cardiovascular death and if impaired relaxation mitral inflow filling pattern is a risk marker.
Methods: Diastolic function was graded by the Mayo Clinic algorithm utilizing the well characterized prospective Olmsted County Heart Function Study.
Over the past two decades, the global incidence of sexually transmitted infections (STIs) such as gonorrhea, chlamydia, and syphilis have increased significantly, particularly among cisgender men who have sex with men (MSM) and transgender women (TGW). This rise in STIs has spurred interest in new preventive measures, including doxycycline post-exposure prophylaxis (DoxyPEP). Clinical trials in the United States and France have demonstrated the effectiveness of DoxyPEP in reducing both chlamydia and syphilis incidence among MSM and TGW; although, its efficacy against gonorrhea remains limited, and it was further found to be ineffective among cisgender women in Kenya.
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- Safe and Sustainable by Design (SSbD) is a new regulatory approach aimed at guiding the development of chemicals and materials, recommended by the European Commission with a focus on a two-stage framework.
- The SSbD process involves setting principles for redesigning materials and assessing their safety and sustainability, but its effectiveness for advanced materials like TiCT MXenes still needs further exploration.
- Research on TiCT MXenes indicates they are safe and sustainable under the SSbD framework, but more studies are required on their long-term effects and the eco-friendly production of titanium, as well as guidance on evaluating the relevant evidence for SSbD assessments.
Article Synopsis
- The chapter explains the process of expressing and purifying myosin, a type of cytoskeletal molecular motor, using an insect cell system.
- It details methods for characterizing the quality of the purified myosin through techniques like mass photometry and negative-stain electron microscopy (EM).
- Lastly, it describes how to conduct in vitro assays to observe how fluorescently labeled myosin moves along actin tracks and mentions adapting these assays for MINFLUX imaging.