Predicting Individual Pain Sensitivity Using a Novel Cortical Biomarker Signature.

Importance: Biomarkers would greatly assist decision-making in the diagnosis, prevention, and treatment of chronic pain.

Objective: To undertake analytical validation of a sensorimotor cortical biomarker signature for pain consisting of 2 measures: sensorimotor peak alpha frequency (PAF) and corticomotor excitability (CME).

Design, Setting, And Participants: This cohort study at a single center (Neuroscience Research Australia) recruited participants from November 2020 to October 2022 through notices placed online and at universities across Australia.

Hotspots and global trends in research of host immune response in periodontitis: A bibliometric analysis.

Background: The host immune response plays a major role in the pathogenesis of periodontitis. A bibliometric study can be crucial to understanding the different processes involved in this area; however, to our knowledge, it has not been published until now. Therefore, a bibliometric analysis was conducted to assess research hotspots and global trends in scientific articles about the immune response in periodontitis published between 1952 and 2023.

Prevalence of respiratory viruses in children in Northeast Brazil: The scenario before the COVID-19 pandemic.

Objectives: To investigate the prevalence of nine respiratory viruses and their clinical characteristics in children aged up to 5 years old in the state of Sergipe, Northeast of Brazil in the pre-COVID-19 pandemic period.

Methods: Children with suspected influenza virus infection were included in the study. Clinical samples were screened using real-time quantitative polymerase chain reaction for the diagnosis of adenovirus, parainfluenza (PIV)1, PIV2, PIV3, and human metapneumovirus.

Immunobiologics in juvenile dermatomyositis: a systematic review of promising therapeutic advances.

Introduction: To identify the most effective treatment for juvenile dermatomyositis (JDM), considering efficacy, safety, impact on patients and improvement in their quality of life.

Material And Methods: A systematic review was carried out comparing known treatments and immunobiological therapies, evaluating clinical improvement, adverse events and prognosis. The MEDLINE, PubMed, LILACS and Cochrane Library databases were used with children aged 0 to 18 diagnosed with JDM.

Label-free proteomic analysis of Duchenne and Becker muscular dystrophy showed decreased sarcomere proteins and increased ubiquitination-related proteins.

Muscular dystrophies (MD) are a group of hereditary diseases marked by progressive muscle loss, leading to weakness and degeneration of skeletal muscles. These conditions often result from structural defects in the Dystrophin-Glycoprotein Complex (DGC), as seen in Duchenne Muscular Dystrophy (DMD) and Becker Muscular Dystrophy (BMD). Since MDs currently have no cure, research has focused on identifying potential therapeutic targets to improve patients' quality of life.