Publications by authors named "J C Appelbaum"
Background: Medical student exposure to role-modeling of high-value care (HVC) behaviors may shape professional identity formation and future HVC practices.
Objective: To investigate the frequency and characteristics of HVC role-modeling witnessed by medical students during core clinical rotations.
Design: Cross-sectional survey study.
Article Synopsis
- Febrile neutropenia (FN) is a leading cause of hospital readmission after chemotherapy in patients with acute myeloid leukemia (AML) and greatly affects healthcare resources.
- The study aimed to find baseline characteristics that could predict which AML patients experiencing FN are at lower risk for progressing to severe illness, focusing on outcomes like hospital stay duration and ICU admissions.
- Out of 397 FN admissions analyzed, only 15% were considered lower-risk, with physiological parameters like heart rate and blood pressure being strong predictors; the study concluded that existing FN risk models are inadequate for AML patients, necessitating the development of a specific FN risk model.
Chimeric antigen receptor (CAR) designs that incorporate pharmacologic control are desirable; however, designs suitable for clinical translation are needed. We designed a fully human, rapamycin-regulated drug product for targeting CD33+ tumors called dimerizaing agent-regulated immunoreceptor complex (DARIC33). T cell products demonstrated target-specific and rapamycin-dependent cytokine release, transcriptional responses, cytotoxicity, and in vivo antileukemic activity in the presence of as little as 1 nM rapamycin.
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