Publications by authors named "J C Aponte"
Human craniofacial shape is highly variable yet highly heritable with numerous genetic variants interacting through multiple layers of development. Here, we hypothesize that Mendelian phenotypes represent the extremes of a phenotypic spectrum and, using achondroplasia as an example, we introduce a syndrome-informed phenotyping approach to identify genomic loci associated with achondroplasia-like facial variation in the general population. We compare three-dimensional facial scans from 43 individuals with achondroplasia and 8246 controls to calculate achondroplasia-like facial scores.
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- * The research simulated the aqueous alteration processes of residues from irradiated interstellar ice, using minerals like serpentinite and the Allende meteorite to study amino acid changes.
- * Results showed that minerals and their types crucially affect the creation and breakdown of amino acids during these simulated experiments.
Readability Level of Spanish Language Online Health Information: A Systematic Review.
Hisp Health Care Int
October 2024
Because there is limited online health information in Spanish and it is critical to raise health literacy among Spanish-speaking people, it is essential to assess the readability level of Spanish material. This systematic review included all articles published up to January 3, 2024, and used the CINAHL, MEDLINE, and PubMed databases. The objective was to include the body of knowledge on published articles on the readability levels of Spanish-language, web-based health information intended for lay audiences.
View Article and Find Full Text PDFWe report primordial aqueous alteration signatures in water-soluble organic molecules from the carbonaceous asteroid (162173) Ryugu by the Hayabusa2 spacecraft of JAXA. Newly identified low-molecular-weight hydroxy acids (HO-R-COOH) and dicarboxylic acids (HOOC-R-COOH), such as glycolic acid, lactic acid, glyceric acid, oxalic acid, and succinic acid, are predominant in samples from the two touchdown locations at Ryugu. The quantitative and qualitative profiles for the hydrophilic molecules between the two sampling locations shows similar trends within the order of ppb (parts per billion) to ppm (parts per million).
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- The World Health Organization recommends HPV vaccination schedules for individuals aged 9-20 years, including studies on single-dose efficacy, particularly focusing on a Phase 3 trial of the Cecolin® vaccine in low- and middle-income countries.
- In this trial, 1,025 girls in Bangladesh and Ghana received various dosing schedules of Cecolin or Gardasil® to evaluate immunological responses and safety after vaccination.
- Interim results showed that the Cecolin vaccine was non-inferior to Gardasil, with 100% seropositivity one month after the second dose, and over 96% seropositivity six months after one dose, indicating strong immunogenicity and comparable safety profiles between the two vaccines.