Publications by authors named "J C Almanza-Perez"
Article Synopsis
- The study addresses the urgent issue of antibiotic resistance by exploring new antimicrobial agents like peptidoglycan hydrolases (PGHs) and ribosomal proteins.
- A strain isolated from fermented meat showed significant antimicrobial activity against various pathogens, with optimal results at high nitrogen levels (5.7 g/L).
- Two proteins, RP uL14 and MupG, were identified and their production was influenced by nitrogen and carbon concentrations, emphasizing the role of nutritional sources in developing new antimicrobial solutions.
Antihyperglycemic and Hypolipidemic Activities of Flavonoids Isolated from Smilax Dominguensis Mediated by Peroxisome Proliferator-Activated Receptors.
Pharmaceuticals (Basel)
October 2024
: Mexican people use Smilax dominguensis as a traditional medicine for diabetes control. Some reports have shown an anti-hyperglycemic effect in animal models. In the current research, a chemical bio-guided fractionation in vitro and in silico was performed to identify compounds with anti-hyperglycemic and hypolipidemic effects through PPARγ/α dual agonist activity because they regulate genes involved in energy storage and burning, such as GLUT4 and FATP.
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- The thalamic reticular nucleus is crucial for processing information in thalamocortical neurons, influenced by GABAergic neurons and their connections with globus pallidus neurons.
- This study focused on the effects of damaging the globus pallidus on the electrical activity and molecular responses of the thalamic reticular nucleus in male rats.
- The results showed that the lesion increased neuron firing frequency and D4 receptor levels, but decreased the expression of the α3 subunit of GABAA receptors, indicating a complex regulatory role of the globus pallidus on thalamic neuron firing.
Bocconia arborea S. Watson (Papaveraceae) is an abundant medicinal plant in the North of Morelos State, Mexico, which is used for the treatment of several diseases. The aim of current investigation was to isolate the compounds responsible of the relaxant effect shown by the active extracts.
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- The study explores the development of a new dual compound design targeting PPARγ and GPR40 for treating type 2 diabetes.
- It highlights Compound 2's effectiveness in increasing mRNA levels of these receptors and significantly enhancing GLUT-4 transporter activity, comparable to an existing diabetes medication, pioglitazone.
- In animal tests, Compound 2 showed promise in regulating glucose levels in diabetic rats without causing hypoglycemia, indicating its potential for safe diabetes management.