Publications by authors named "J C Aleksandrowicz"

The short generation time of many bacterial pathogens allows the accumulation of mutations during routine culture procedures used for the preparation and propagation of bacterial stocks. Taking the major human pathogen Streptococcus pneumoniae as an example, we sought to determine the influence of standard laboratory handling of microbes on within-strain genetic diversity and explore how these changes influence virulence characteristics and experimental outcomes. A single culture of S.

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Objectives: To check the legitimacy of the presumption that there are many "neurotic" disorders.

Methods: Taxonomic analyzes by single linkage method, unweighted pair-group average and Ward's method, also k-means clustering. The material in the pilot study used the information obtained from the Symptom Checklist "O", completed before treatment by 4,649 patients, who applied for treatment due to various functional disorders.

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Peptides derived from the HR1 or HR2 regions of the HIV-1 envelope glycoprotein gp41 have been shown to be effective inhibitors to prevent virus-host cell membrane fusion. These peptide drugs, however, suffer from relatively short plasma half-lives and are susceptible to enzymatic degradation. Modification of peptides/proteins with poly(ethylene glycol) (PEG) is a well-established strategy to overcome these limitations.

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Aim: Symptom checklists enable clinicians and researchers to quickly estimate the probability of neurotic disorder presence. To pursue this goal, they should include a possibly limited number of items, describing symptoms most prevalent in the disordered population. Fluctuations in that prevalence force researchers to prepare new variants of checklists every few years, therefore the next (current) version of the checklist "S" for screening has been prepared.

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