Using technology to harmonise treatment approaches in colposcopy in the face of a changing environment.

The overall numbers of precancerous lesions are expected to fall as human papillomavirus (HPV) vaccinated women enter the cervical screening programme. Juxtaposed against an increase in referrals from the introduction of primary high-risk HPV screening, colposcopists expect to see a decreasing incidence of high-grade cervical intraepithelial neoplasia (CIN). Correct identification of lesions will become more challenging, as the prevalence of high-grade lesions becomes minimal and conventional colposcopy is subject to a lower sensitivity.

Directing assembly of DNA-coated colloids with magnetic fields to generate rigid, semiflexible, and flexible chains.

We report the formation of colloidal macromolecules consisting of chains of micron-sized paramagnetic particles assembled using a magnetic field and linked with DNA. The interparticle spacing and chain flexibility were controlled by varying the magnetic field strength and the linker spring constant. Variations in the DNA lengths allowed for the generation of chains with an improved range of flexibility as compared to previous studies.

Organosiloxane supramolecular liquids--surface-energy-driven phase transitions.

Autocondensation of organoalkoxysilanes and subsequent anion exchange produces organosiloxane supramolecular liquids which are core-free and solvent-free nanoparticle nanofluids. This hybrid supramolecular liquid, [C(81)H(156)NO(3)S(SiO([2>x>3/2]))](y), exhibits (see TEM image; 200 nm width) interparticle menisci and softness (from imputed deformations) of interparticle potential.

Multidisciplinary colposcopy clinicopathology correlation meetings: an activity review.

Objective: Multidisciplinary colposcopy clinicopathology correlation meetings are deemed to be an important aspect of colposcopic quality assurance and are often a focus of attention in colposcopy quality assurance peer-review assessments. Despite this, there are few data on such meetings detailing activity or providing benchmarks for audit.

Materials And Methods: A retrospective analysis of clinicopathology correlation meetings held during a 3-year period (2004-2006) at the University Hospital of North Staffordshire was performed.

The diagnostic accuracy of colposcopy in previously treated cervical intraepithelial neoplasia.

Objective: To determine whether colposcopy is reliable in diagnosing cervical intraepithelial neoplasia in women who have undergone a previous cervical excision biopsy.

Materials And Methods: A prospective study of women attending the colposcopy clinic at the University Hospital of North Staffordshire was performed between January 1998 and December 1999.

Results: A clear histological diagnosis of the grade of cervical intraepithelial neoplasia was available for 469 in the treatment-naive group and 58 in the treatment group.