Publications by authors named "J Bustamante"

Introduction: The purpose of this study was to explore the implications of the in-field implementation of a teaching strategy that promotes critical thinking (TPCT) on tactical ability, declarative, and procedural knowledge. The TPCT is grounded in socio-constructivist theory and aims to enhance players' analytical skills through inquiry, problem-solving, and observation. By emphasizing the socio-constructivist approach, the program fosters skills such as interpretation, analysis, inference, evaluation, explanation, and self-regulation, encouraging players' active participation in questioning and collaborative problem-solving activities.

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Studies of microbial communities vary widely in terms of analysis methods. In this growing field, the wide variety of diversity measures and lack of consistency make it harder to compare different studies. Most existing alpha diversity metrics are inherited from other disciplines and their assumptions are not always directly meaningful or true for microbiome data.

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Article Synopsis
  • Inborn errors of immunity (IEIs) are genetic disorders that increase the risk of infections, autoimmunity, and other health issues, and often show incomplete penetrance despite being caused by single gene mutations.
  • This study examines how autosomal random monoallelic expression (aRMAE)—where only one allele of a gene is actively expressed—contributes to the variability in disease outcomes among individuals within families with IEIs.
  • The findings reveal that specific gene expression patterns related to aRMAE can influence clinical phenotypes, suggesting that understanding both genetic and expression variations is crucial for analyzing the impact of monogenic disorders.
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The spectrum of known monogenic inborn errors of immunity is growing, with certain disorder underlying a specific and narrow range of infectious diseases. These disorders reveal the core mechanisms by which these infections occur in various settings, including inherited and acquired immunodeficiencies, thereby delineating the essential mechanisms of protective immunity to the corresponding pathogens. These findings also have medical implications, facilitating diagnosis and improving the management of individuals at risk of disease.

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