Publications by authors named "J Burggraaf"
From setbacks to success: lessons from the journey of RSV vaccine development.
Ther Adv Vaccines Immunother
December 2024
Respiratory syncytial virus (RSV) causes high worldwide infant mortality, as well as a high disease burden in the elderly. Efforts in vaccine development over the past 60 years have recently delivered three approved vaccines and two monoclonal antibodies (mAbs). Looking back at the eventful history of RSV vaccine development, several factors can be identified that have hampered the developmental pathway, including the occurrence of enhanced RSV disease (ERD) in the first vaccine attempt and the difficulty in characterizing and stabilizing the pre-fusion F protein as a vaccine target.
View Article and Find Full Text PDFArticle Synopsis
- - Oesophageal cancer patients achieving a clinical complete response (CR) after neoadjuvant chemoradiotherapy (nCRT) may benefit from active surveillance; however, identifying true CRs is difficult due to a 40% regrowth rate in these patients.
- - The study examined pre-treatment and post-treatment tissue samples to analyze the expression of several tumor markers (CEA, EpCAM, VEGF-α, EGFR, c-MET) through immunohistochemistry, aiming to find markers for potential near-infrared fluorescence imaging.
- - Results showed high expression of EpCAM in adenocarcinomas and EGFR in squamous cell carcinomas, while neoadjuvant therapy did not alter the
Purpose: Tumor-targeted positron emission tomography (PET) and fluorescence-guided surgery (FGS) could address current challenges in pre- and intraoperative imaging of gastric cancer. Adequate selection of molecular imaging targets remains crucial for successful tumor visualization. This study evaluated the potential of integrin αβ, carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), epidermal growth factor receptor (EGFR), epithelial cell adhesion molecule (EpCAM) and human epidermal growth factor receptor-2 (HER2) for molecular imaging of primary gastric cancer, as well as lymph node and distant metastases.
View Article and Find Full Text PDFArticle Synopsis
- * A new imaging agent, AKRO-6qcICG, can be applied to the surface of these tumors and helps surgeons see where cancer cells remain during surgery using near-infrared fluorescence.
- * In studies with patients, AKRO-6qcICG showed excellent sensitivity (100%) in detecting remaining cancer cells, indicating it could be a valuable tool to improve surgical outcomes and minimize additional treatments.
Purpose: Cysteine cathepsins are proteases that play a role in normal cellular physiology and neoplastic transformation. Elevated expression and enzymatic activity of cathepsins in breast cancer (BCa) indicates their potential as a target for tumor imaging. In particular cathepsin B (CTSB), L (CTSL), and S (CTSS) are used as targets for near-infrared (NIR) fluorescence imaging (FI), a technique that allows real-time intraoperative tumor visualization and resection margin assessment.
View Article and Find Full Text PDF