A scoping review on intraoperative and postoperative surgical castration complications in domesticated equids.

Background: Castration is the most common surgical procedure in domesticated equids; surgical techniques used and perioperative management vary considerably.

Objectives: To identify and chart the current evidence on perioperative complications associated with different methods of surgical castration in domesticated equids.

Study Design: Joanna Briggs Institute systematic scoping review.

UK horse owners and veterinary practitioners' experiences of decision-making for critical cases of colic.

Background: The survival of horses diagnosed with critical colic (requiring referral or euthanasia) relies on rapid and effective decision-making by the owner and veterinary practitioner.

Objectives: To explore UK horse owners' and veterinary practitioners' experiences of decision-making for critical cases of equine colic.

Study Design: Qualitative study using a phenomenological approach.

Multicenter study investigating long-term survival after synovial lavage of contaminated and septic synovial structures in horses presented to 10 UK referral hospitals.

Objective: To report the long-term survival of adult horses that were subjected to synovial lavage for treatment of contaminated and septic synovial structures.

Study Design: Multicenter, prospective observational trial.

Animals: Horses (n = 240) presented for synovial sepsis at 10 UK referral centers.

Neuronally differentiated macula densa cells regulate tissue remodeling and regeneration in the kidney.

Tissue regeneration is limited in several organs, including the kidney, contributing to the high prevalence of kidney disease globally. However, evolutionary and physiological adaptive responses and the presence of renal progenitor cells suggest an existing remodeling capacity. This study uncovered endogenous tissue remodeling mechanisms in the kidney that were activated by the loss of body fluid and salt and regulated by a unique niche of a minority renal cell type called the macula densa (MD).

Navigating the Landscape of Translational Geroscience in Canada: A Comprehensive Evaluation of Current Progress and Future Directions.

The inaugural Canadian Conferences on Translational Geroscience were held as 2 complementary sessions in October and November 2023. The conferences explored the profound interplay between the biology of aging, social determinants of health, the potential societal impact of geroscience, and the maintenance of health in aging individuals. Although topics such as cellular senescence, molecular and genetic determinants of aging, and prevention of chronic disease were addressed, the conferences went on to emphasize practical applications for enhancing older people's quality of life.