Publications by authors named "J Burchell"
Article Synopsis
- - Avian poxvirus infections can present in two main forms: cutaneous pox with skin nodules and diphtheritic pox with exudate in respiratory and gastrointestinal tracts; systemic spread is rare but observed in some cases.
- - Over 20 years, 22 out of 151 diagnosed cases at a zoological institution showed systemic involvement, revealing lesions in organs like the liver, spleen, and kidneys, with two histopathologic patterns identified.
- - Genetic analysis confirmed that systemic cases shared identical DNA sequences with a previously identified condorpox virus, suggesting that specific viral strains and various host/environmental factors may contribute to systemic infections.
Tumor-associated macrophages (TAMs) are a heterogeneous population of cells that facilitate cancer progression. However, our knowledge of the niches of individual TAM subsets and their development and function remain incomplete. Here, we describe a population of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1)-expressing TAMs, which form coordinated multi-cellular "nest" structures that are heterogeneously distributed proximal to vasculature in tumors of a spontaneous murine model of breast cancer.
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- Infections, particularly from specific parasites, are prevalent in both wild and captive passerine birds, with some species co-evolving with certain parasites.* -
- The severity of disease can range from mild to fatal, which raises concerns for institutions managing endangered bird species, especially in mixed-species settings.* -
- Research aimed at understanding the host-specificity of these parasites has shown that genetic sequences mainly align with specific bird species, indicating a need for further investigation on interspecies transmission and disease risk factors.*
Epigenetic regulation of gene expression is crucial to the determination of cell fate in development and differentiation, and the Polycomb (PcG) and Trithorax (TrxG) groups of proteins, acting antagonistically as complexes, play a major role in this regulation. Although originally identified in Drosophila, these complexes are conserved in evolution and the components are well defined in mammals. Each complex contains a protein with methylase activity (KMT), which can add methyl groups to a specific lysine in histone tails, histone 3 lysine 27 (H3K27), by PcG complexes, and H3K4 and H3K36 by TrxG complexes, creating transcriptionally repressive or active marks, respectively.
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