Publications by authors named "J Burch"
Using a high-throughput screening (HTS) approach, a new GTP-site binding pyridine-carboxylate series of cGAS inhibitors was discovered. The biochemical potency of this new pyridine carboxylate series was improved 166-fold from the original hit to double-digit nanomolar levels using structure-based design insights, but the series was found to suffer from low permeability and low bioavailability. A structure-based hybridization of the metal-binding motifs of the pyridine carboxylate series and our previously disclosed tetrahydrocarboline GTP-site ligand identified pyrimidine amide compound .
View Article and Find Full Text PDFInsomnia symptoms and the risk of all-cause mortality among stroke survivors.
BMC Public Health
December 2024
Article Synopsis
- This study explored the link between insomnia symptoms and the risk of death among stroke survivors using data from the Health and Retirement Study, focusing on participants over 50 with a history of stroke from 2002 to 2018.
- Out of 3,501 stroke survivors monitored for an average of 6 years, it was found that insomnia symptoms, particularly difficulties in initiating and maintaining sleep, were linked to a higher risk of mortality in young male stroke survivors, but no such link was found for females.
- The findings suggest that insomnia may significantly increase the risk of all-cause mortality in younger male stroke survivors, indicating a need for further research in this area, especially since these results were not
Article Synopsis
- Autonomic rehabilitation using osteopathic manipulative treatment (OMT) aims to stimulate the vagus nerve and improve heart rate variability (HRV), which reflects the health of the autonomic nervous system.
- A study was conducted on 30 healthy osteopathic medical students to assess the effects of a specific OMT technique on HRV before and after treatment.
- Results showed significant increases in key HRV measures post-OMT, indicating improved vagal tone and potential benefits for autonomic nervous system function.*
Within biology, there have been long-standing goals to understand how traits impact fitness, determine the degree of adaptation, and predict responses to selection. One key step in answering these questions is to study the mode of gene action or genetic architecture of traits. The genetic architecture underlying a trait will ultimately determine whether selection can lead to a change in the phenotype.
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- Microcrystal electron diffraction (microED) is a new technique for quickly analyzing small molecule crystals, particularly useful in pharmaceuticals.
- In a study involving 30 samples from Amgen Inc., researchers successfully determined the structures of 15 crystals using just 40 hours of microscope time.
- All chiral compounds analyzed had their absolute stereochemistry correctly assigned through dynamic refinement, showcasing the effectiveness of dynamic refinement in determining stereochemistry for pharmaceutical compounds.