Publications by authors named "J Bucuvalas"
Pediatric liver transplant outcomes exhibit disparities, necessitating identification of modifiable risk factors to develop targeted interventions. We characterized associations between household material economic hardship (e.g.
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- - The study aimed to evaluate the effectiveness of short (<120 days) versus long (>180 days) antiviral prophylaxis for preventing cytomegalovirus (CMV) disease in pediatric liver transplant recipients by analyzing data from the Society of Pediatric Liver Transplantation registry between 2015 and 2019.
- - Among the 199 enrolled participants, shorter prophylaxis resulted in higher occurrences of CMV DNAemia (26.8% vs. 13.8%) and CMV syndrome (18.8% vs. 6.9%) compared to longer prophylaxis, while end-organ disease rates were similar between the two groups.
- - Long prophylaxis was associated with a significantly higher incidence of neutropenia (55
Article Synopsis
- - The Banff Working Group on Liver Allograft Pathology convened in September 2022 with a diverse group of experts to discuss long-term health monitoring of liver transplants, focusing on noninvasive methods and optimizing immunosuppression.
- - The group considered revising the rejection classification scheme to better identify and communicate late T cell-mediated rejection patterns and related changes, like nodular regenerative hyperplasia.
- - They emphasized the need for personalized immunosuppression strategies based on individual patient needs and proposed incorporating interface hepatitis and fibrosis staging into the rejection classification, which will undergo further testing and discussion before the next conference.
Impact of early immunosuppression on pediatric liver transplant outcomes within 1 year.
J Pediatr Gastroenterol Nutr
February 2024
Objectives: The Starzl Network for Excellence in Pediatric Transplantation identified optimizing immunosuppression (IS) as a priority practice improvement area for patients, families, and providers. We aimed to evaluate associations between clinical characteristics, early IS, and outcomes.
Methods: We analyzed pediatric liver transplant (LT) data from 2013 to 2018 in the United Network for Organ Sharing (UNOS) and the Society of Pediatric Liver Transplantation (SPLIT) registries.