Stroke-induced neuroplasticity in spiny mice in the absence of tissue regeneration.

Stroke is a major cause of disability for adults over 40 years of age. While research into animal models has prioritized treatments aimed at diminishing post-stroke damage, no studies have investigated the response to a severe stroke injury in a highly regenerative adult mammal. Here we investigate the effects of transient ischemia on adult spiny mice, Acomys cahirinus, due to their ability to regenerate multiple tissues without scarring.

Utilization of Alternative Fibres Manufactured from Recycled PET Bottles in Concrete Technology for the Improvement of Fire Resistance.

This article addresses the potential use of secondary polymer fibres in the field of structural concrete as a replacement for primary polymer fibres (mainly polypropylene/PP/), which are used in concrete to enhance its resistance when exposed to high temperatures (especially in the case of fire). Research has shown that, in addition to PP fibres, polyethylene terephthalate/PET/fibres, produced by recycling packaging materials (mainly PET bottles), can also be used as an alternative. These fibres are industrially produced in similar dimensions as PP fibres and exhibit similar behaviour when added to fresh and hardened concrete.

Therapeutic targeting of RNA for neurological and neuromuscular disease.

Neurological and neuromuscular diseases resulting from familial, sporadic, or de novo mutations have devasting personal, familial, and societal impacts. As the initial product of DNA transcription, RNA transcripts and their associated ribonucleoprotein complexes provide attractive targets for modulation by increasing wild-type or blocking mutant allele expression, thus relieving downstream pathological consequences. Therefore, it is unsurprising that many existing and under-development therapeutics have focused on targeting disease-associated RNA transcripts as a frontline drug strategy for these genetic disorders.

Spaceflight effects on human vascular smooth muscle cell phenotype and function.

The cardiovascular system is strongly impacted by the hazards of spaceflight. Astronauts spending steadily increasing lengths of time in microgravity are subject to cardiovascular deconditioning resulting in loss of vascular tone, reduced total blood volume, and diminished cardiac output. Appreciating the mechanisms by which the cells of the vasculature are altered during spaceflight will be integral to understanding and combating these deleterious effects as the human presence in space advances.

N-methyladenosine in 7SK small nuclear RNA underlies RNA polymerase II transcription regulation.

N-methyladenosine (mA) modifications play crucial roles in RNA metabolism. How mA regulates RNA polymerase II (RNA Pol II) transcription remains unclear. We find that 7SK small nuclear RNA (snRNA), a regulator of RNA Pol II promoter-proximal pausing, is highly mA-modified in non-small cell lung cancer (NSCLC) cells.