Publications by authors named "J Bruchfeld"
Article Synopsis
- Post-acute COVID-19 syndrome (PACS) occurs in patients even after mild infections, and this study investigates the link between PACS and microvascular endothelial dysfunction.* -
- Out of 92 PACS patients, 41% showed signs of microvascular endothelial dysfunction, with increased levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) correlated to this dysfunction.* -
- The findings suggest that microvascular endothelial dysfunction is common in PACS, particularly in those with rising NT-proBNP levels, highlighting the need for further research on this condition.*
Article Synopsis
- Postural orthostatic tachycardia syndrome (POTS) affects about 30% of individuals with post-COVID-19 condition, leading to significant physical and psychological limitations.
- A study evaluated tailored endurance and strength training over 12 weeks for 26 participants, with high adherence rates (76% for exercise and 96% completion).
- The intervention showed improvements in symptoms and physical/psychological functions, suggesting that future research can be conducted with minor adjustments to the evaluation methods used.
Objectives: Linezolid treatment has a high risk of toxicity and adverse drug reactions (ADR) are frequent. Few studies have investigated risk factors of major ADRs separately, therefore, we aimed to evaluate major ADRs including peripheral neuropathy in relation to risk factors and drug concentration levels of linezolid in a high-resource setting for multidrug-resistant tuberculosis (MDR-TB).
Methods: We conducted a retrospective cohort study including participants treated with a linezolid-containing MDR-TB regimen in Sweden 1992-2018.
Background: The management of multidrug-resistant tuberculosis (MDR-TB) remains challenging. Treatment outcome is influenced by multiple factors; the specific roles of diabetes and glycemic control remain uncertain. This study aims to assess the impact of glycemic control on drug exposure, to investigate the association between drug exposure and treatment outcomes, and to identify clinically significant thresholds predictive of treatment outcome, among patients with diabetes.
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