Publications by authors named "J Brillard"

Article Synopsis
  • The study explores how
  • epigenetic inheritance
  • , specifically DNA methylation, contributes to the adaptation of the plant pathogen
  • Ralstonia pseudosolanacearum
  • to different host plants over many generations, challenging the traditional view that adaptation is solely based on genetic mutations.
  • Researchers analyzed the
  • methylomes
  • of evolved bacterial clones and found
  • 50 differential methylated sites (DMSs)
  • associated with the EpsR regulator gene, suggesting a possible connection between these epigenetic changes and adaptation.
  • The study highlights that rapid epigenetic changes can facilitate quick adaptation, and certain changes in DNA methylation may persist for long periods, indicating a potential mechanism for long-term adaptation in bacterial pathogens.*
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is a Gram-negative bacterium, mutualistically associated with the soil nematode , and this nemato-bacterial complex is parasitic for a broad spectrum of insects. The transcriptional regulator OxyR is widely conserved in bacteria and activates the transcription of a set of genes that influence cellular defence against oxidative stress. It is also involved in the virulence of several bacterial pathogens.

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Glycerol is a cryoprotectant used widely for the cryopreservation of animal sperm, but it is linked to a decrease in fertility. The mechanism underlying the negative effects of glycerol remains unclear. Therefore, in this study, we aimed to gain a better understanding by using the chicken model.

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In bacteria, DNA-methyltransferase are responsible for DNA methylation of specific motifs in the genome. This methylation usually occurs at a very high rate. In the present study, we studied the MTases encoding genes found in the entomopathogenic bacteria Xenorhabdus.

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Bacteria have evolved sophisticated mechanisms to deliver potent toxins into bacterial competitors or into eukaryotic cells in order to destroy rivals and gain access to a specific niche or to hijack essential metabolic or signaling pathways in the host. Delivered effectors carry various activities such as nucleases, phospholipases, peptidoglycan hydrolases, enzymes that deplete the pools of NADH or ATP, compromise the cell division machinery, or the host cell cytoskeleton. Effectors categorized in the family of polymorphic toxins have a modular structure, in which the toxin domain is fused to additional elements acting as cargo to adapt the effector to a specific secretion machinery.

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