Publications by authors named "J Brewin"
The spleen is prone to both physical damage and functional impairment, which can be difficult to detect before catastrophic complications occur. Currently available tests of splenic function are laborious, user-dependent and unreliable, so there is an unmet need for a reliable test offered routinely in diagnostic laboratories. In this study, we have assessed a simple flow cytometry-based method measuring high mannose glycans (HMGs) on erythrocytes, which has previously been proposed as a potential test of splenic function.
View Article and Find Full Text PDFIneffective erythropoiesis (IE) is defined as the abnormal differentiation and excessive destruction of erythroblasts in the marrow, accompanied by an expanded progenitor compartment and relative reduction in the production of reticulocytes. It is a defining feature of many types of anemia, including beta-thalassemia. GATA1 is an essential transcription factor for erythroid differentiation, known to be implicated in hematological conditions presenting with IE, including beta-thalassemia and congenital dyserythropoietic anemia.
View Article and Find Full Text PDFArticle Synopsis
- A study was done to see how doctors help patients decide on treatments for a condition called benign prostatic hyperplasia (BPH) and if they would choose differently for themselves.
- Doctors filled out a survey about their experiences and choices in treating BPH, showing that most had more experience with older methods than new ones.
- Many doctors preferred a specific treatment called HoLEP for themselves, but they might not offer it as often to their patients, suggesting they need more practice with newer techniques.