Publications by authors named "J Brent"
Background: Tramadol is an adulterant of illicit opioids. As it is a serotonin-norepinephrine reuptake inhibitor as well as a μ-opioid agonist, tramadol adulteration may worsen overdose signs and symptoms or affect the amount of naloxone patients receive.
Methods: This is a multicenter, prospective cohort of adult patients with suspected opioid overdoses who presented to one of eight United States emergency departments and were included in the Toxicology Investigators Consortium's Fentalog Study.
Objectives: Although considerable focus has been placed on understanding the causes of opioid drug overdoses, the intentions for such overdoses are not well characterized. We investigated the motivations behind nonfatal opioid exposures resulting in serious adverse health outcomes.
Methods: We analyzed prospectively collected data on nonfatal opioid overdoses in the multicenter Toxicology Investigators Consortium (ToxIC) Core Registry between 2014 and 2021.
Article Synopsis
- Opioid overdose deaths in the U.S. have dramatically increased due to the rise of illicit fentanyl, which also raises the risk of HIV infection among those affected by injection drug use.
- A study analyzed data from 1,690 patients who experienced acute opioid overdoses across 10 hospitals to identify HIV prevalence and associated risk factors.
- The findings revealed that 5.6% of patients with known HIV status were HIV positive, with stimulant use being more common among HIV-positive individuals and a significant link found between bipolar psychiatric history and increased HIV risk.