Publications by authors named "J Brennand"
Article Synopsis
- The study investigates the link between pre-eclampsia and pre-existing cardiac dysfunction in pregnant women, finding no significant increase in overall pre-eclampsia rates.
- A modest rise in cases of preterm pre-eclampsia and a significant increase in fetal growth restriction (FGR) were observed among women with cardiac issues.
- The findings suggest that while there are concerns regarding pregnancy outcomes in this group, the relationship between cardiac dysfunction and pre-eclampsia is not clearly causal, and the use of β-blockers may have an impact on birthweight.
Objective: To determine maternal, obstetric and neonatal outcomes in a cohort of women with primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC).
Design: Retrospective cohort study.
Setting: Ten specialist centres managing pregnant women with liver disease.
Objective: To assess median and percentile birthweight distribution in women with various groups of heart disease relative to a contemporaneous comparison group.
Methods: Data on birth weight and gestational age were collected from 1321 pregnancies ≥24 weeks' gestation in 1053 women with heart disease from seven UK maternity units. Women were assigned to one of 16 groups according to their cardiac lesion.
Female renal transplant recipients of childbearing age may ask what the outcomes are for pregnancy and whether pregnancy will affect graft function. We analyzed obstetric and transplant outcomes among renal transplant recipients in our center who have been pregnant between 1973 and 2013. A case-cohort study was performed identifying 83 pairs of pregnant and non-pregnant controls matched for sex, age, transplant vintage, and creatinine.
View Article and Find Full Text PDFObjective: Circulating biomarkers of endothelial dysfunction and inflammation are elevated in late pregnancy in women with preeclampsia. We examined plasma levels of inflammatory cytokines and adhesion molecules in early pregnancy, to assess their ability to predict preeclampsia.
Methods: In a prospective longitudinal study, 2600 women with singleton pregnancies and no history of hypertension were recruited at their antenatal hospital (booking) visit at gestational week 12-16.