Normal values of quantitative T2' in a spontaneously hypertensive stroke prone rat stem at 3T.

Introduction: Regarding therapy and prognosis of acute ischemic stroke the identification of ischemic penumbra is pivotal. A promising candidate is BOLD-imaging using qT2'-maps. For valid interpretation of experimental studies in animals normal values for qT2' are needed.

Comparison between early and delayed systemic treatment with candesartan of rats after ischaemic stroke.

Objective: The effects of candesartan treatment starting early (3 h) and delayed (24 h) after middle cerebral artery occlusion (MCAO) with reperfusion was investigated in normotensive rats.

Methods: Subcutaneous treatment with candesartan (0.3 and 3 mg/kg) or vehicle was initiated 3 or 24 h after the onset of MCAO and continued for seven consecutive days (n=20 per group and timepoint).