Publications by authors named "J Bravais"
Background And Objectives: Krebs von den Lungen-6 (KL-6), expressed by damaged type II pneumocytes, is useful in the diagnosis and severity assessment of many diffuse interstitial lung diseases. The objective of our study was to determine the prognostic value of the initial KL-6 plasma level in COVID-19 pneumonia.
Methods: All patients hospitalized for a suspected COVID-19 pneumonia between March and May 2020 in our Chest department of a French university hospital were included.
Cell and cytokine analyses from bronchoalveolar lavage (BAL) in non-critically ill patients with COVID-19 pneumonia are poorly described. This study focused on patients hospitalized in the non-intensive care unit for either suspected COVID-19 pneumonia or persistent respiratory symptoms following proven COVID-19 pneumonia. Overall, 54 patients who underwent BAL between April 2020 and February 2021 for suspected or follow-up of proven COVID-19 pneumonia were included.
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- High prevalence of obstructive sleep apnea (OSA) is linked to worsening idiopathic pulmonary fibrosis (IPF), and intermittent hypoxia (IH) from OSA appears to worsen lung fibrosis.
- A study used C57BL/6J mice to assess how IH affects lung fibrosis induced by Bleomycin (BLM), either by pre-exposing the mice to IH or exposing them simultaneously with BLM.
- Results indicated that prior exposure to IH led to significant weight loss, increased lung injury, and higher levels of pro-fibrotic markers, with notable increases in ER stress markers, highlighting the detrimental impact of IH on lung fibrosis progression.