Publications by authors named "J Bradley Layton"
Introduction: The clinical landscape for the treatment of patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) is rapidly evolving. As part of the FOUNTAIN platform (NCT05526157; EUPAS48148), we described and compared cohorts of adult patients with CKD and T2D initiating a sodium-glucose cotransporter 2 inhibitor (SGLT2i) before the launch of finerenone in Europe, Japan, and the United States (US).
Methods: This was a multinational, multi-cohort study of patients with T2D in five data sources: the Danish National Health Registers (DNHR) (Denmark), PHARMO Data Network (The Netherlands), Valencia Health System Integrated Database (VID) (Spain), Japan Chronic Kidney Disease Database Extension (J-CKD-DB-Ex) (Japan), and Optum's de-identified Clinformatics Data Mart Database (CDM) (US).
Article Synopsis
- * A quality improvement project aimed at using academic detailing (AD) was conducted to educate primary care providers on screening, referral, and treatment for opioid use disorder, alongside available community resources.
- * While the project did not lead to increased screening or prescribing practices for opioid use disorder, it successfully improved providers' knowledge of local resources, revealing time constraints as a key barrier to implementing such services.
Article Synopsis
- The study investigates Alzheimer's disease-related psychosis (ADP) in older adults, focusing on demographic and clinical differences between those treated with antipsychotics and those who are not.
- Researchers analyzed data from over 145,000 ADP patients, comparing health outcomes related to falls, fractures, seizures, and mortality between the two groups.
- Findings reveal that antipsychotic users had more baseline health issues and higher rates of falls, fractures, and mortality compared to nonusers, indicating a significant impact of antipsychotic treatment on health outcomes in ADP patients.
Background: Real-world evidence (RWE) plays a key role in regulatory and healthcare decision-making, but the potentially fragmentated nature of generated evidence may limit its utility for clinical decision-making. Heterogeneity and a lack of reproducibility in RWE resulting from inconsistent application of methodologies across data sources should be minimized through harmonization.
Methods: This paper's aim is to describe and reflect upon a multidisciplinary research platform (FOUNTAIN; FinerenOne mUlti-database NeTwork for evidence generAtIoN) with coordinated studies using diverse RWE generation approaches and explore the platform's strengths and limitations.
Marine science is widely recognized as one of the least diverse fields within geoscience. Despite substantial investments in diversity initiatives and resources aimed at engaging underserved communities, the representation and recognition of Black individuals in marine science remain limited. This lack of representation highlights a broader issue: a shortage of professionals who are attuned to the pressing issues within Black communities.
View Article and Find Full Text PDF