Publications by authors named "J Bost"
Article Synopsis
- The PECOS study is investigating the long-term effects of pediatric SARS-CoV-2 infections by comparing infected and uninfected participants aged 0-21.
- Participants were assessed on various health metrics, including symptom reports, physical exams, and psychological surveys, revealing that those infected reported significantly worse outcomes in several health domains.
- The findings indicate that SARS-CoV-2 infection could negatively impact children's overall quality of life, highlighting the importance of ongoing research to understand these long-term effects.
Background: Chronic red blood cell (RBC) transfusion is an established therapy to prevent stroke in patients with sickle cell anemia (SCA). It is unclear if adding daily hydroxyurea treatment to chronic transfusion is beneficial.
Study Design And Methods: We conducted a phase 2 clinical trial (NCT03644953) investigating the addition of dose-escalated hydroxyurea to chronic transfusion for patients with SCA receiving simple chronic transfusion for stroke prevention.
Article Synopsis
- Plasmon decay is a key process that helps transfer hot carriers between plasmonic nanoparticles and semiconductor surfaces, which could enhance electronic applications.
- The study employs real-time time-dependent density functional theory (RT-TDDFT) simulations, revealing that plasmon decay in silver (Ag) nanoparticles on hydrogen-terminated Si(111) surfaces occurs over 100 femtoseconds, and is over twice as fast compared to free space.
- The simulations show that this rapid plasmon decay generates nearly 30% of holes deep in the semiconductor's valence band, highlighting the usefulness of the Wannier gauge approach for studying complex electron dynamics.
Background: The aim of the study was to evaluate the effectiveness of a novel e-learning module in teaching the physical exam of the temporomandibular joint (TMJ) in Juvenile idiopathic arthritis (JIA.).
Methods: An e-learning module was developed to convey the TMJ physical examination maneuvers that are considered to be best practice in JIA.
Introduction: Quality of life (QOL) is critical in screening and management of chronic medical conditions, including celiac disease (CD). The aim of this project was to develop a CD-specific pediatric QOL measure (Celiac Disease Life Inventory of Family Experiences [CDLIFE]) with parallel self-report and parent-report forms by generating items through concept elicitation interviews, iterative refinement using cognitive debriefing interviews, and evaluating its psychometric properties and validity.
Methods: Concept elicitation interviews were conducted to develop items (9 youth ages 8-19 years with CD; 10 parents of youth with CD), followed by cognitive interviews with additional stakeholders (3 youth with CD, 3 parents, and 8 clinicians) and item administration (parent/youth reports: n = 103/102).