Publications by authors named "J Bosso"
Article Synopsis
- - Racial disparities affect the age at which individuals complete aspirin desensitization and receive a diagnosis for ASA-exacerbated respiratory disease (AERD).
- - Having public insurance is linked to receiving an official AERD diagnosis after the age of 50.
- - Social factors, such as race and insurance status, play a significant role in AERD diagnosis and the ability to adhere to aspirin desensitization protocols.
Background: Viral infections have long been implicated in the development of chronic rhinosinusitis with nasal polyps (CRSwNP). Given widespread exposure to the common cold coronavirus 229E (HCoV229E), we sought to investigate how HCoV-229E is cleared and stimulates interferon pathways in air-liquid interface (ALI) cultures from patients with CRSwNP.
Objective: The objective of this study was to identify whether viral clearance and ISG expression is different in ALI cultures from donors with CRSwNP compared with controls.
Assessing adequacy of surgical extent in CRSwNP: The Completion of Surgery Index.
Int Forum Allergy Rhinol
January 2025
Article Synopsis
- Endoscopic sinus surgery (ESS) is effective for treating nasal polyps, but the extent of surgery can vary, making it crucial to know when revision surgery is needed, especially with new treatments available.
- A new Completion of Surgery Index (CoSI) was created to evaluate the effectiveness of surgery in polyp patients by comparing CT scans before and after the procedure.
- In a study of 100 patients, those needing revision surgery showed significant improvements in quality of life, with CoSI scores indicating that those with lower preoperative scores benefited more from the surgery, helping to identify candidates for future interventions.
There is currently interest regarding CRSsNP patients with refractory symptomatology following functional endoscopic sinus surgery, and which of these patients can derive benefit from low-dose macrolide therapy. In the present study, we analyze a cohort of over fifty CRSsNP patients on macrolide therapy; structured histopathological findings at the time of surgery were analyzed against the success of macrolide treatment. Independently, fibrosis, absence of squamous metaplasia, absence of eosinophilia, presence of neutrophilic infiltrate, and lymphoplasmocytic predominance were all associated with objective success of macrolide treatment; these findings may allow clinicians to more appropriately select patients for this therapy.
View Article and Find Full Text PDFA stepwise approach to the adult immunodeficiency evaluation for the rhinologist.
Curr Opin Otolaryngol Head Neck Surg
February 2024
Purpose Of Review: Patients with an immunodeficiency may present to their Rhinologist with a history of recurrent, severe, and chronic infections. Therefore, it is essential for the Rhinologist to have a basic understanding of clinically relevant immune deficiencies.
Recent Findings: After describing different types of immunodeficiencies, their presentations, and management strategies, an evaluation algorithm is described.