The Use of a Penta-Deuterophenyl Substituent to Improve the Metabolic Stability of a Tyrosine Kinase Inhibitor.

In cases in which a rapid metabolism is the cause of an unfavorable pharmacokinetic profile, it is important to determine the Sites of Metabolism (SoMs) of a molecule to introduce the necessary modifications to improve the stability of the compound. The substitution of hydrogen atoms by deuterium atoms has been proposed to ameliorate such properties due to the greater stability of the C-D bonds. , bearing a 2-phenylamino substituent, is a compound previously described by our group with good biological activity as a discoidin domain receptor (DDR2) inhibitor but suffers from low metabolic stability determined in a test with rat-liver microsomes (less than 50% of the initial compound after 60 min).

Supplementing Silicoglycidol for the reduction of aflatoxin M in milk and biomarkers of liver dysfunction in dairy cows.

Aflatoxin M (AFM) is a pathogenic metabolite transferred from feed into milk from aflatoxin (AF) B, B, G, and G; thus, it poses a human health risk. Therefore, effective mitigation strategies are needed to reduce animal and human exposure to AF. Study objectives were to evaluate a dietary adsorbent (Silicoglycidol, ATX) as a sequestering agent in AF-contaminated feed and to broadly examine how AF affects liver function and the immune system.

Applying Molecular Modeling to the Design of Innovative, Non-Symmetrical CXCR4 Inhibitors with Potent Anticancer Activity.

The identification of new compounds with potential activity against CXC chemokine receptor type 4 (CXCR4) has been broadly studied, implying several chemical families, particularly AMD3100 derivatives. Molecular modeling has played a pivotal role in the identification of new active compounds. But, has its golden age ended? A virtual library of 450,000 tetraamines of general structure was constructed by using five spacers and 300 diamines, which were obtained from the corresponding commercially available cyclic amines.

Agrobiodiversity conservation enables sustainable and equitable land sparing.

Intensifying agriculture to spare land for nature could help meet competing food security and biodiversity conservation goals. However, this approach neglects and undervalues agrobiodiversity, currently maintained by millions of smallholder farmers. For intensification to be sustainable and land sparing to be achieved equitably, we must conserve high-agrobiodiversity landscapes.