Publications by authors named "J Borneman"
Article Synopsis
- - A subset of patients with inflammatory bowel disease (IBD) shows an increase in a harmful gut bacteria known as adherent-invasive E. coli (AIEC), which is connected to mutations in the protein tyrosine phosphatase type 2 (PTPN2) gene that disrupts gut microbiota balance.
- - The study examines how the host protein CEACAM6, which AIEC uses to invade intestinal cells, is regulated in the context of the PTPN2 gene and its variants, finding that patients with specific SNPs have higher CEACAM6 levels.
- - Experimental cell lines with altered PTPN2 expression showed increased adhesion and invasion by AIEC, indicating that the absence of PTP
Article Synopsis
- The study explores how the protein tyrosine phosphatase non-receptor type 2 (PTPN2) gene affects the colonization of a specific harmful bacteria, AIEC, in the intestines, which is linked to inflammatory bowel disease (IBD).
- Researchers used genetically modified mice to compare the effects of AIEC and a non-invasive strain on intestinal bacteria levels, immune response, and barrier function.
- Results showed that mice lacking PTPN2 had greater AIEC colonization, lower levels of protective proteins, and increased intestinal permeability, highlighting the gene's critical role in maintaining gut health.
Aims: Huanglongbing (citrus greening) is a plant disease putatively caused by the unculturable Gram-negative bacterium Candidatus Liberibacter asiaticus (CLas), and it has caused severe damage to citrus plantations worldwide. There are no definitive treatments for this disease, and conventional disease control techniques have shown limited efficacy. This work presents an in silico evaluation of using specifically targeting anti-microbial peptides (STAMPs) consisting of a targeting segment and an antimicrobial segment to inhibit citrus greening by inhibiting the BamA protein of CLas, which is an outer membrane protein crucial for bacterial viability.
View Article and Find Full Text PDFHigh fat diets (HFDs) have been linked to several diseases including obesity, diabetes, fatty liver, inflammatory bowel disease (IBD) and colon cancer. In this study, we examined the impact on intestinal gene expression of three isocaloric HFDs that differed only in their fatty acid composition-coconut oil (saturated fats), conventional soybean oil (polyunsaturated fats) and a genetically modified soybean oil (monounsaturated fats). Four functionally distinct segments of the mouse intestinal tract were analyzed using RNA-seq-duodenum, jejunum, terminal ileum and proximal colon.
View Article and Find Full Text PDFIntroduction: Sensory inference and top-down predictive processing, reflected in human neural activity, play a critical role in higher-order cognitive processes, such as language comprehension. However, the neurobiological bases of predictive processing in higher-order cognitive processes are not well-understood.
Methods: This study used electroencephalography (EEG) to track participants' cortical dynamics in response to Austrian Sign Language and reversed sign language videos, measuring neural coherence to optical flow in the visual signal.