Publications by authors named "J Boltze"
Sustained activation of the SIRT3-NLRP3 inflammasome has been associated with worse outcomes after ischemic stroke. The objective of this study was to examine the potential mechanism by which the SIRT3-NLRP3 inflammasome affects neural stem and progenitor cells (NSPCs) after transient middle cerebral artery occlusion (tMCAO) in rats. Following tMCAO, significantly elevated levels of NLRP3, ASC, cleaved caspase 1, IL-1β, and IL-18 were observed in the ischemic subventricular zone.
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- Huntington's disease (HD) is a progressive neurodegenerative condition leading to cognitive, movement, and behavioral issues, ultimately causing disability and death.
- This study evaluates the effectiveness of a transgenic sheep model (OVT73) for PET imaging to track brain metabolism and dysfunction related to HD.
- Findings reveal that younger HD sheep show increased glucose uptake in specific brain regions compared to healthy controls, while both older HD sheep displayed reduced dopamine binding potential, highlighting the potential of this model for studying HD progression.